Phentermine is a popular appetite suppressant drug that affects one’s central nervous system. It is a psychostimulant belonging to the phenethylamine class and is similar to amphetamine. The drug is used in combination with exercising and dietary regimen to treat obesity. Overweight people can suffer from various health complications such as diabetes, high blood pressure and high cholesterol.
The Phentermine drug received its approval from FDA in the year 1959. From the early 1970s, Phentermine hydrochloride became readily available in the market. The medication was initially sold under the name of Fastin from the King Pharmaceuticals for the SmithKline Beecham. However, Fastin was later removed from market. Gate Pharmaceuticals sold the drug as Adipex-P and nowadays Phentermine is also sold generically.
How does Phentermine work?
Phentermine affects the hypothalamus area of the brain which stimulates the adrenal glands. This helps to secrete norepinephrine, a chemical messenger or neurotransmitter targets triggers a fight-or-flight response which reduces hunger. The medication also works outside one’s brain to release adrenaline or epinephrine, which helps to break down the fat stored in the fat cells. Reduction of hunger is the principal basis of its efficiency. Phentermine also gives out serotonin and dopamine when administered at clinically relevant proportions. However, the amount of these substances released is much less than that of the norepinephrine.
Phentermine Brand Names
One of the principal brands manufacturing this medication is the Adipex-P. The other well-known Phentermine brands include
- Pro-Fast SA
The anorectic agent Phentermine hydrochloride is the ingredient that is actively used in this drug. The inactive components of the drug are listed below:
- Shellac glaze
- Dibasic calcium
- Propylene glycol
- Titanium dioxide
- Magnesium stearate
- Phosphate dihydrate
Phentermine Forms and Strengths
This drug is available in the market in the form of tablets and capsules. Disintegrating or mouth-dissolving Phentermine tablets can also be obtained. Prescribed dosages of this medicine can be for 15 mg, 30 mg, or Phentermine 37.5 mg.
Phentermine Side Effects
The catecholamine-releasing properties of the Phentermine drug can produce various effects like elevated blood pressure and tachycardia. As this medication acts through the sympathomimetic pathways, it may increase one’s heart rate and blood pressure. Other side effects include restlessness, palpitations and insomnia. Phentermine can additionally cause psychological dependency in individuals who take this drug regularly. The drug is only meant for a short term use, after which the body develops tolerance for this medication, resulting in rebound weight gain.
The various side effects caused by this medication include
- Bizarre behavior
- Overactive reflexes
- Shortness of breath
- Aggressive tendencies
- Seizures or convulsions
- Irregular blood pressure
- Irregular or fast heartbeat
- Frequent changes of mood
- Primary pulmonary hypertension
- Severe or constant light-headedness
- Regurgitant valvular disease of the heart